Moderna's monovalent shot contains 50 micrograms of mRNA per dose targeting the original strain. The updated booster shots c ontain the same number of micrograms, with 15 targeting the original strain and the other 15 targeting BA.4 and BA.5. The new shots have the same dosage amounts as the original vaccines, which further suggests that their safety profiles could be similar, Offit says.Ī single dose of Pfizer's monovalent vaccine contains 30 micrograms of mRNA targeting the original Covid strain. The same concept held true during the last round of booster shots. You're only eligible for the new boosters if you've completed a primary vaccination series, meaning most people will have already received at least two doses ahead of time. Severe side effects are "generally" most common after receiving a second dose of a vaccine, not after receiving a third or fourth dose, says Offit. Moderna's trial found that nearly 59% of participants experienced fatigue, but only about 4% experienced that at a Grade 3 level, which is defined as significant fatigue that prevents daily activity. Roughly 26% of participants experienced a mild or moderate headache, while only 0.3% experienced a severe one. Pfizer's trial found that about 52% of participants that received the BA.1 shot experienced mild pain at the injection site, 8% experienced moderate pain and only 0.3% experienced severe pain. But notably, in those clinical trials, the severity of the side effects was very mild. That's a familiar list: It's the same group of side effects that came with the original formulations.
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